Spiritual awakening refers to a profound shift in an individual’s consciousness or understanding of themselves and their world. It is becoming more aware of one’s spiritual nature, often characterized by a sense of inner peace, clarity, and connection to something greater than oneself.
Concentrated young woman with a hair bun holding mala beads while performing spiritual practice outdoors
Various experiences, such as a life-changing event, a personal crisis, or a mystical experience, can trigger a spiritual awakening. It is often accompanied by a sense of heightened intuition and deepening one’s connection to the natural world and other living beings.
During a spiritual awakening, individuals may experience various physical, emotional, and psychological symptoms, including heightened sensitivity, changes in sleeping patterns, and a shift in priorities and values. They may also experience a sense of detachment from material possessions and a desire for simplicity and authenticity.
Spiritual awakening is a profoundly personal and individual process that can take many forms. Some people may experience a sudden and dramatic shift in their consciousness, while others may experience a gradual and subtle transformation over time.
While a spiritual awakening can be a powerful and transformative experience, it can also be challenging and disorienting. Many people seek out spiritual teachers, practices, and communities to help them navigate this process and integrate their new understanding into their daily lives.
Psychedelics have been known to induce powerful and transformative experiences that some people describe as spiritual or mystical. These experiences can involve a sense of unity with all things, a dissolution of the ego, and a deep connection to a higher power or consciousness.
While some people may describe these experiences as spiritual awakenings, it’s important to note that the use of psychedelics does not guarantee a spiritual awakening, and not everyone who uses psychedelics will have a spiritual experience. Additionally, the effects of psychedelics can vary widely depending on the individual, the dose, the setting, and other factors.
It’s also important to note that while psychedelics can induce temporary changes in consciousness and perception, lasting spiritual growth and transformation often require ongoing personal work and spiritual practice.
Furthermore, the use of psychedelics carries some potential risks and side effects, including psychological distress, physical harm, and legal consequences. It should only be used under appropriate medical supervision and in legal settings.
Overall, while psychedelics can be a tool for spiritual exploration and growth, they should be used with caution and in conjunction with other spiritual practices and self-exploration to integrate any insights or experiences into one’s life fully.
Speak to a professional before engaging in any activities that might be harmful to your physical and mental health. Shangriballa offers Free Screening Calls to all clients.
We recommend The Third Wave website as a trusted resource for education and reputable retreats.
Mystical experiences are profound spiritual or religious experiences characterized by a deep sense of interconnectedness, unity, and transcendence. They are often described as transcending the limitations of the individual self and experiencing a sense of oneness with the universe or a higher power.
Mystical experiences have been reported throughout human history and are found in almost all religious and spiritual traditions. They can occur spontaneously, as in a sudden feeling of unity with all things, or they can be induced through various practices such as meditation, prayer, or the use of psychedelic substances.
One of the defining characteristics of mystical experiences is a sense of ineffability. Those who have had a mystical experience often struggle to find the words to describe it, as it seems to transcend language and concepts. However, some common themes emerge in descriptions of mystical experiences. These include:
Unity and interconnectedness: Mystical experiences often involve a feeling of unity with all things. The boundaries between the self and the world dissolve, and one experiences a sense of interconnectedness with everything around them.
Transcendence of time and space: Mystical experiences can also involve a sense of timelessness and spacelessness. The individual may feel as though they are outside of time and space or that time and space are irrelevant to the experience.
Sense of awe and wonder: Mystical experiences often leave individuals with a deep sense of awe and wonder. They may feel as though they have encountered something greater than themselves and that this encounter has changed them profoundly.
Feeling of peace and joy: Many people with mystical experiences report a deep sense of peace and joy. They may feel they have tapped into a source of inner peace and contentment that is not dependent on external circumstances.
Encounter with a higher power: Mystical experiences can involve encounters with a higher power or spiritual presence. Depending on the individual’s religious or spiritual beliefs, this can take many forms.
Psychologists, neuroscientists, and philosophers have studied mystical experiences. Some researchers have suggested that they may be related to altered states of consciousness, such as those induced by meditation or psychedelic substances. Others have proposed that mystical experiences are a natural part of the human experience and may be related to the evolution of the brain.
Regardless of their origins, mystical experiences can profoundly transform individuals. They can inspire feelings of compassion, empathy, and connection with others and help individuals develop a deeper understanding of the world around them. For those who have had a mystical experience, it is often seen as a life-changing event, a moment of clarity that reveals the deeper truths of existence.
Spiritual bypassing refers to using spiritual beliefs or practices to avoid dealing with uncomfortable or painful emotions, psychological wounds, or personal issues. It involves using spiritual practices to avoid or deny the difficulties of everyday life, such as relationships, work, and personal challenges.
Spiritual bypassing can manifest in many ways, such as using meditation to escape emotional pain, avoiding difficult conversations by focusing on positive thinking, or dismissing others’ suffering by claiming that they just need to “raise their vibration” or “align with the universe.”
While spiritual practices can benefit personal growth and healing, spiritual bypassing can hinder this process by avoiding the necessary work of facing and addressing inner conflicts and challenges. This can lead to a lack of emotional maturity, detachment from reality, and a sense of spiritual superiority that can alienate others and undermine genuine connection and growth.
It’s important to approach spiritual practices with mindfulness and honesty, acknowledging and working through difficult emotions and challenges rather than using spirituality to avoid them.
To avoid spiritual bypassing, it’s important to approach spiritual practices with mindfulness and honesty, acknowledging and working through difficult emotions and challenges rather than using spirituality as a way to avoid them. Here are some specific tips:
How to Avoid Spiritual Bypassing
Cultivate self-awareness: Reflect on your motivations and intentions for engaging in spiritual practices. Are you using them to escape uncomfortable emotions or challenges? Are you seeking to feel superior or avoid dealing with difficult situations? Being honest with yourself can help you avoid spiritual bypassing.
Practice emotional intelligence: Emotions are a natural part of life, and it’s important to develop the skills to recognize, understand, and work with them. Spiritual practices can help you develop emotional intelligence by cultivating mindfulness and compassion, but it’s also important to seek professional help if you’re struggling with intense emotions or psychological issues.
Avoid spiritual superiority: Spiritual bypassing often involves a sense of spiritual superiority, where individuals believe they are more evolved or enlightened than others. This can lead to a lack of empathy and understanding toward others and ultimately undermine genuine growth and connection.
Seek balance: Spiritual practices should be balanced with everyday life, including work, relationships, and personal challenges. It’s important to integrate spiritual practices into your daily routine in a way that supports your personal growth and healing rather than using them to escape or avoid difficult situations.
Seek community and support: Connection with others can provide valuable support and accountability as you work to avoid spiritual bypassing. Seek out communities or groups that share your spiritual values and engage in open and honest dialogue about your experiences and challenges.
Can I use Ayahuasca and Marijuana together? Many retreats around the world are reporting similar experiences when working with people who use Marijuana. Ayahuasca is unpredictable and works with people in a unique and personalised way. No two people report the same experience. Having multiple ayahuasca ceremonies makes one realise that every ceremony is different.
Most people have a strong experience with Ayahuasca, but there are some for whom the medicine has no effect. I have seen this in many people, and the exact reason is unknown. Many of them were heavy Marijuana/ Herbal remedy users or took pharmaceutical medication for long periods.
The majority of people who reported no experience were heavy Marijuana users in the last year. Heavy use is when you use Marijuana four to five times a week. Light use a few times a month does not seem to impact the experience. However, even after heavy use of Marijuana is stopped for a few months before coming on retreat, it still influences the clients’ experience with Ayahuasca.
Heavy users can still have a powerful experience during a ceremony, and there are reports of people having just that, but around 70% of heavy users will be affected.
Although the results of working with either Ayahuasca and Marijuana can facilitate expansiveness and healing, the way they work with us to create these transformations are complete opposites; they are different pants with different energies. Like two doctors specialising in different modalities to bring balance but mixing them could influence each other.
The powerful detoxing effects of Kambo can assist in detoxing the body. Marijuana users that have stopped for more than three months could benefit from having Kambo before Ayahuasca. The amount of Kambo sessions that are needed before an Ayauahuasca ceremony will depend on how long you have been off Marijuana and how much you used.Please contact me if you are interested in working with Kambo for Marijuana use. The Ayahuasca and Marijuana Use
Purging Your Digestive Tract for More Effective Absorption, How can Ayahuasca and Marijuana Use be fixed?
Purging is a significant aspect of using both kambo and ayahuasca. With ayahuasca, though, it is often thught of as a side-effect or something endured during the initial phases of the experience in order to reach the peak. On the other hand, purging while using kambo is one of the main goals. And when kambo is used to purge your system before taking ayahuasca, it can increase the speed and efficacy of the absorption of ayahuasca, giving you a cleaner, more intense experience at a lower dosage.
Although kambo and ayahuasca both cause purging, kambo’s unique chemical makeup makes it more intense. The main peptide in kambo that causes purging is called phyllomedusin. It causes increased salivation and stimulates smooth muscles to contract, which causes vomiting and diarrhoea. Throughout the process, you will likely vomit and use the bathroom several times. This will allow you to expel undigested food and digestive juices such as bile. Bile, secreted by the liver, coats your digestive tract and aids digestion by breaking down fats and allowing them to be absorbed into the bloodstream. By getting rid of the bile in your stomach and intestines, your body doesn’t have a chance to reabsorb the toxins before they are expelled. This leaves your body ready to absorb and break down the chemicals in ayahuasca.
Since some people do not experience purging when they take ayahuasca or do not experience it until later in the ceremony, purging with kambo before taking ayahuasca can greatly change the experience. For one thing, the purging during the ayahuasca ceremony may be less intense so you are better able to concentrate on the psychological effects of the ayahuasca. It can also make you less likely to pass the tea through your digestive system and out of your body, making lower doses more efficient and allowing you to experience the physical and psychological effects of the ayahuasca sooner. This can give you or your practitioner greater control over your ayahuasca dose and can potentially lead to a safer, more manageable experience.
Increasing Circulation to Facilitate Crossing of the Blood-Brain Barrier. Ayahuasca and Marijuana Use
The peptides phyllomedusin and phyllokinin—both present in kambo— are potent blood vessel dilators. As the kambo begins to circulate through your body, your blood vessels will expand, allowing the peptides to cross over your blood-brain barrier more easily. Your blood vessels will remain dilated, and you will experience increased blood circulation for a short time after the treatment. If you take ayahuasca during this period, the active ingredients will reach your brain more quickly after you ingest the tea and more of the substance will cross over into your brain, increasing the effectiveness of the substance.
This increased effectiveness can give your practitioner greater control over your experience. Usually, there is a waiting period after you ingest the tea before you reach peak effects. The amount of time it takes before you begin feeling the effects depends on your personal chemistry. With more immediate results, your practitioner will be able to monitor the depth of your experience more closely and can make sure you have an experience at the level you are ready for. However, it is important that your practitioner is familiar with how kambo can interact with ayahuasca so that they lower your initial dose and prepare you for more immediate, intense results.
Easing You Into Psychedelic Experiences
Kambo has a unique position in the world of psychedelics because it can cause a sense of emotional euphoria or well-being. Still, it does not cause hallucinations or non-ordinary states of consciousness. Ayahuasca, on the other hand, is more of a classic psychedelic in that it creates an obvious shift in your consciousness, changing the way you perceive the world for a short period. Because of these differences, kambo can be a useful introduction to the world of psychedelics and prepare you for a more psychologically intense ayahuasca experience.
If you have never experienced a classic psychedelic, it’s normal to feel a bit apprehensive. Taking kambo first can be a less intimidating introduction to psychedelics since your basic perception of the world will not be changed during your experience. For this reason, you may choose to try kambo for several weeks or even months before you try ayahuasca. However, take kambo within 24 hours of taking ayahuasca. The euphoria and sense of wellness that kambo produces can help you feel more relaxed and open to the psychological benefits of an ayahuasca experience.
Creating Greater Awareness of Your Body Before a Psychedelic Treatment
For many people, one of the most important aspects of an ayahuasca ceremony is the blending of spiritual and physical awareness. While some people prefer an inward journey that allows them to stop concentrating on their body in order to reflect on their mind and emotions, others find it helpful to connect intense mental and emotional thoughts with physical experiences. These people often have a desire to walk, dance, sing, chant, or otherwise express themselves physically while under the influence of ayahuasca. For those who prefer this type of psychedelic experience, kambo can help you become more aware of your body through its intense physical effects.
Besides purging, kambo produces other noticeable physical effects such as a flushing, tingling sensation in your limbs and face and slight swelling in your extremities and around your eyes. These physical sensations, experienced with your normal awareness, can help you become more aware of your body. At the same time, two of the peptides in kambo—caerulein and sauvagine—will stimulate your adrenal cortex. This can create heightened sensory perception and increased stamina and is why kambo was often used before a hunting trip. All these effects create an increased sense of your physical body which can, in turn, help you connect the spiritual ayahuasca experience with your physical existence.
Kambo and ayahuasca have been used together traditionally, and now, more Western practitioners are beginning to understand the benefits of preparing your body with kambo shortly before an ayahuasca ceremony. Although both substances have benefits when used independently, their effects can be heightened and controlled more carefully when used together. Suppose you are interested in taking kambo before an ayahuasca ceremony. In that case, it is important to discuss your intentions with an experienced practitioner and make a plan that is both safe and effective.
Ayahuasca is a powerful medicine and teacher plant that brings deep multi-level healing physically, emotionally, mentally, and spiritually. While ayahuasca and other medicinal plants may address a very large number of issues, they are not a cure-all or magic bullet.
At Shangriballa we are blessed to have pure spring water that comes from the mountain. We are the first in line to the source of water 800 meters above sea level. We have waterfalls and natural pools where we conduct our water ceremonies.
In South Africa, I worked with a shaman/sangoma that worked mainly with water to heal. For years I worked with her and got to understand how powerful this element was. Water is the lifeblood of our mother earth the holiest being we will ever get to touch in this incarnation, used correctly water can bring balance and health.
She trained me to work with water and how to do spiritual baths, water root and river ceremonies. It was through her blessing and initiation that I now use water as a healing modality. Water was one of the first elements that came into existence, and that makes it an ancient substance filled with wisdom.
People search the world for sacred water sites where they can immerse and experience oneness with God. Healing water rituals have existed in all cultures since recorded time and are thought to have existed in pre-historic cultures for millions of years. Most ancient cultures maintain spiritual creation stories crediting water as the origin of life.
Mythological stories of water deities have been passed down through oral traditions, and many continue to live on in modern religions and ceremonial traditions. Every culture on earth has a spiritual reverence for water and uses water symbolically in ceremonies, christenings, baptisms, and initiations.
Many shrines have been constructed to praise the element of water; and often, these particular sites attract hundreds of thousands of people who make regular pilgrimages to participate in water healing rituals.
When water emerges from underground it is right there where it experiences its first exposure to light. This is the water that is thought to be most sacred, having emerged with all the resonance of the heart of the Earth still within its cells. These sacred wellsprings may be found in very remote places.
It is no surprise that people will travel through rugged terrain and suffer hardship in order to touch those pure waters. When the water has flowed over rocks, minerals, soil and roots, the energies present in each molecule are bursting with electromagnetic energy and have not been distorted by human contact or toxic resonance.
For thousands of years, cultures have performed water ceremonies.
Water Ceremonies in Egypt
Egyptian Priest and Anubis (Lord of the Dead) pouring water and water over King preparing him for his journey through the afterlife. The symbol of the Ankh represents water in the following pictures. The hieroglyphs depict Egyptian priest was bathing an Egyptian King with water and herbs depicted as ankh’s and one holding a sceptre in one hand and an ankh which represent eternal life.
Nile Water Ceremony Bath of Infants
Many believe that the Nubian infant bathing rituals date back to ancient Egypt. Generally, the ritual baths took place seven days after the birth of the child. A procession consisting of family and community elders walk to the river singing chants to the child’s spirit and asking the deities of the River Nile to protect and bless the child’s incarnation.
Food prepared by older women is offered to the Nile as a sacrifice while the men send a miniature boat with a white candle lite as a guild for the child’s earthly longevity. Many West African ethnic groups still perform the seven-day ceremony. For instance, among the Akans and Ga of Ghana, the birth ritual is done to confirm that the child was here to stay and would not return to the realm of the spirits.
Many of these rituals were brought from Africa to the Americas and continues to this day.
Piankhi Orders Soldiers to do Sacred Bath in the Nile
Piankhi /Piye of the 25th Dynasty of Egypt/ KMT has written one of the oldest military ritual baths in ancient history. Piankhi ruled over much of the modern-day Sudan and Egypt. He was a Nubian and recorded his military victory on a Stela. Piankhi considered his military conquest of Upper Egypt as a holy war to restore the shrines and temples. When his army entered the sacred city of Thebes, he ordered his men to do a ritual bath of the Nile stating
“When ye arrive at Thebes, before Karnak, ye shall enter into the water; ye shall bathe in the river, ye shall dress in [fine white linen], unstring the bow, loosen the arrow..”
The text above describes the Emperor’s religious preoccupation with paying homage to the unseen frequencies and powers that control the Nile. It is a glaring example of ritual purification, spiritual revitalization and cultural renewal. Ritual Baths in the Bible
Ritual baths in the Bible were quite common. The oldest documented account of a spiritual ritual bath occurs in the Old Testament. John the Baptist were well known for doing his baptisms in rivers. There are many accounts of healing in and with water in Christianity.
“Where a spring rises or water flows, there ought we to build altars and offer sacrifices.” Lucius Annaeus Seneca4 B.C. – 65 B.C
In this article, we share Kambo Research that I have gathered over time. Some of the Kambo Research is based on individual peptides contained in Kambo, not the total secretion.
Lymphatic System and Kambo Research
We know Kambo works on the Lymphatic system and this is why it is a powerful detox. Understanding what the lymphatic system is and what it does gives us a greater understanding of how Kambo can assist the body in naturally healing itself.
The Lymphatic System is a drainage network of fluid, organs, and vessels that is responsible for the removal of cellular debris, large proteins, foreign bodies, pathogenic agents, viruses, toxins, etc.; and excess fluid from the extracellular that moves through the Lymphatic system, which acts as active purification centres.
The primary lymphoid organs include the bone marrow. The secondary lymphoid organs include the spleen, appendix, tonsils, adenoids and Peyer’s patches (lymphoid tissue present in the small and large intestines). Their function is to defend the body against aggressive agents entering the body or to destroy accumulated wastes.
There are approximately 6 to 10 litres in the body, compared to 3.5 to 5 litres of blood.; About 1.5 to 2 litres of lymph per day circulate throughout the whole body. Efficient circulation activation can increase this number from 10 to 30 litres per day. Lymph vessels slowly increase in size, moving lymph toward its entry into the circulatory system behind the heart. The lymphatic system is not connected to the heart, so it has to rely upon some other method, usually muscular contraction, to create the necessary pumping action needed to move lymph. The lymphatic system is filled with millions of one-way valves, which allow lymph fluid to flow in one direction only; usually upward and away from gravity.
Lymph passes through processing and collection centres called lymph nodes. These nodes act as filtration and purification stations for lymph circulation, capturing and destroying toxins and Capturing cancer cells.
There are from 400 up to 1,000 nodes in the human body, more than one-half located in the abdomen ( This might explain why Kambo is felt strongly in the gut). Understanding the Lymphatic system helps us understand Kambo Research more.
Kambo Research and Antimicrobial peptides from Phyllomedusa frogs: from biomolecular diversity to potential nanotechnologic medical applications Leonardo de Azevedo Calderon • Alexandre de Almeida E. Silva •Pietro Ciancaglini • Rodrigo Guerino Sta´beli.
Screening for new bioactive peptides in South American anurans have been pioneered in frogs of the genus Phyllomedusa. All frogs of this genus have venomous skin secretions, i.e., a complex mixture of bioactive peptides against potential predators and pathogens that presumably evolved in a scenario of predator-prey interaction and defence against microbial invasion. For every new anuran species studied, new peptides are found with homologies to hormones, neurotransmitters, antimicrobials, and several other peptides with unknown biological activity. From Vittorio Erspamer findings, this genus has been reported as a ‘‘treasure store’’ of bioactive peptides, and several groups focus their research on these species.
Kambo Research and Antitumor and Angiostatic Activities of the Antimicrobial Peptide Dermaseptin B2. Hanneke van Zoggel, Gilles Carpentier, Ce´lia Dos Santos, Yamina Hamma-Kourbali, Jose´ Courty, Mohamed Amiche, Jean Delbe´ * Laboratoire de Recherche sur la Croissance Cellulaire, la Re´paration et la Re´ge´ne´ration Tissulaires, Universite´ Paris Est – Cre´teil, Cre´teil, France
Recently, we have found that the skin secretions of the Amazonian tree frog Phyllomedusa bicolor contain molecules with antitumor and angiostatic activities and identified one of them as the antimicrobial peptide dermaseptin (Drs) B2. In the present study we further explored the in vitro and in vivo antitumor activity of this molecule and investigated its mechanism of action. We showed that Drs B2 inhibits the proliferation and colony formation of various human tumor cell types, and the proliferation and capillary formation of endothelial cells in vitro. Furthermore, Drs B2 inhibited tumor growth of the human prostate adenocarcinoma cell line PC3 in a xenograft model in vivo. Research on the mechanism of action of Drs B2 on tumor PC3 cells demonstrated a rapid increasing amount of cytosolic lactate dehydrogenase, no activation of caspase-3, and no changes in mitochondrial membrane potential. Confocal microscopy analysis revealed that Drs B2 can interact with the tumor cell surface, aggregate and penetrate the cells. These data together indicate that Drs B2 does not act by apoptosis but possibly by necrosis. In conclusion, Drs B2 could be considered as an interesting and promising pharmacological and therapeutic leader molecule for the treatment of cancer.
Kambo Research and Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two ,u opioid receptor subtypes that modulate antinociception and catalepsy in rats.
Three naturally occurring dermorphin-like peptides from the skin of the frog PhyUomedusa bicolor, the related carboxyl-terminal amides, and some substituted analogs were synthesized, their binding profiles to opioid receptors were determined, and their biological activities were studied in isolated organ preparations and intact animals. The opioid binding profile revealed a very high selectivity of these peptides for IA sites and suggested the existence of two receptor subtypes, of high and low affinity. The peptides tested acted as potent IA opioid agonists on isolated organ preparations. They were several times more active in inhibiting electrically evoked contractions in guinea pig ileum than in mouse vas deferens. When injected into the lateral brain ventricle or peritoneum of rats, the high-affinity-site-preferring ligand, [Lys7-NH21dermorphin, behaved as a potent analgesic agent. By contrast, the low-affinitysite-preferring ligand, [Trp4,Asn7-NH2]dermorphin, produced a weak antinociception but an intense catalepsy.
Kambo Research and Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for 6 opioid binding sites.
Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs belonging to the genus PhyUomedusa, that have a higher affinity and selectivity for 6 opioid binding sites than any other natural compound known. Two deltorphins with the sequence Tyr-Ala-Phe-Asp(or Glu)- Val-Val-Gly-NH2 have been isolated from skin extracts of PhyUomedusa bicolor. The alanine in position 2 is in the D configuration. These peptides, [D-Ala2]deltorphins I and II, show an even higher affinity for 6 receptors than the previously characterized deltorphin, which contains D-methionine as the second amino acid. These peptides show some similarity to another constituent of Phylomedusa skin, dermorphin, which is highly selective for ,u-opioid receptors. These peptides all have the N-terminal sequence Tyr-D-Xaa-Phe, where D-Xaa is either D-alanine or D-methionine. While this structure seems to be capable of activating both pA and 6 opioid receptors, differences in the C-terminal regions of these peptides are probably responsible for the observed high receptor selectivity of dermorphin and deltorphin.
Kambo Research and Frog secretions and hunting magic in the upper Amazon: Identification of a peptide that interacts with an adenosine receptor.
A frog used for “hunting magic” by several groups of Panoan-speaking Indians in the borderline between Brazil and Peru is identified as PhyUomedusa bicolor. This frog’s skin secretion, which the Indians introduce into the body through fresh burns, is rich in peptides. These include vasoactive peptides, opioid peptides, and a peptide that we have named adenoregulin, with the sequence GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV as determined from mass spectrometry and Edman degradation. The natural peptide may contain a D amino acid residue, since it is not identical in chromatographic properties to the synthetic peptide. Adenoregulin enhances binding of agonists to Al adenosine receptors; it is accompanied in the skin secretion by peptides that inhibit binding. The vasoactive peptide sauvagine, the opioid peptides, and adenoregulin and related peptides affect behavior in mice and presumably contribute to the behavioral sequelae observed in humans.
The dermaseptins belong to a superfamily of host defense peptides that are made in the skin of Hylidae frogs. These peptides are genetically related, with a remarkable identity in signal sequences and intervening sequences of their preproforms, but they have markedly diverged to yield several families of peptides that are structurally and functionally distinct. These include the dermaseptins (stricto sensu), the phylloseptins, the plasticins, the dermatoxins, the phylloxins, the raniseptins, the caerin-related peptides, the caerins, the fallaxidins, the frenatins, and the aureins. Most of these peptides are cidal against wall-less bacteria, Gram-negative and Gram-positive bacteria, fungi, protozoa, yeast, and enveloped viruses but are weakly toxic against mammalian cells. Their antimicrobial activity results from their capacity to bind to the bacterial plasma membrane, thereby triggering transient wormhole formation or membrane disruption.
Kambo Research and PHARMACOLOGICAL DATA ON PHYLLOKININ (BRADYKINYL-ISOLEUCYL-TYROSINE O-SULPHATE) AND BRADYKINYL-ISOLEUCYL-TYROSINE
Phyllomedusa rohdei, a small Brazilian amphibian, contains in its skin, in addition to a number of inactive polypeptides, at least three peptides active on plain muscle. The first one (polypeptide a) is characterized by a stimulant action on the rat uterus and the rat colon combined with a moderate hypotensive action in the dog; the second (polypeptide b) by a typical bradykinin-like activity; the third (polypeptide c) by a physalaemin-like activity (cf. Bertaccini, Cei & Erspamer, 1965a, 1965b). The three polypeptides may be separated from each other by chromatography on alkaline alumina column followed by elution with descending concentrations of ethanol. Polypeptide a emerges from the column in the 95% ethanol eluates, polypeptide b in the 70% ethanol eluates, and polypeptide c in the 60% and 50% ethanol eluates. Polypeptide a is possibly a tryptophan-containing pentapeptide, the synthesis of which is in progress; polypeptide c has not yet been obtained in a pure state; polypeptide b has been isolated and identified as bradykinyl-isoleucyl-tyrosine 0-sulphate (Anastasi, Erspamer, Bertaccini & Cei, unpublished). The proposed structure has been confirmed by synthesis (Bernardi, Bosisio, De Castiglione & Goffredo, 1966). For the new naturally occurring bradykinin-like endecapeptide the name of phyllokinin has been suggested. This paper describes some of the pharmacological actions of natural and synthetic phyllokinin in comparison with synthetic bradykinyl-isoleucyl-tyrosine and with synthetic bradykinin.
Kambô, The Spirit of the Shaman by Marcelo Bolshaw Gomes, Professor of Sociology of Communication UFRN (Federal University of Rio Grande do Norte, Natal)
“Kambô circulates in the heart. Our shaman said that when we take Kambô, it makes the heart move accurately so that things flow, bringing good things to the person. It is as if there was a cloud on the person, preventing the good things to come, then, when it takes the Kambô; it comes a ‘green light’, which opens its ways, making things easier”
Kambo Research and its Multitude of Biological Effects: Adverse Events or Pharmacological Effects?
Kambo is the name of a secretion of a tropical frog, the Phyllomedusa bicolor or giant leaf frog from the Amazonian forest, which has been used for centuries by local tribes to enhance their hunter skills. Its first tribal use was described in 1925, and included the first effects after administration of the secretion: nausea and vomiting. Since the end of last century Kambo is introduced in Europe and the USA as a ‘healing’ intervention to cleanse the bodily systems, it is regarded as a ‘detox’ intervention. Method: We reviewed all available literature related to adverse events and pharmacological effects of the active peptides in Kambo. Result: The secretion of the frog consists several bioactive peptides and within few minutes after intake, nausea, vomiting, facial edema, palpitations and hypotension can occur. In the pharmacological and medical literature, these are reported as transient adverse events, although in essence the reactions are purely pharmacological. We will present and discuss its adverse events, the pharmacological basis of these events and present contraindications and recommendations for safe use.
Kambo Research, Peptides & Proteins (thanks to Hans Börner)
We talk a lot about the peptides in Kambo, but what are they? In this paper, Hans gives an in-depth explanation of Peptides and proteins.
Read the full paper here. ( This is a scientific paper and can be challenging to understand. I have included a second article that is easier for the layman to understand. Peptidevorlesung
Kambo is a traditional Amazonian remedy from the secretion of the Phyllomedusa bicolour tree frog. It has been used by several indigenous cultures in the Amazon rainforest, and these people revere its powerful, purgative therapy. In these traditional cultures, they capture the tree frogs in the forest, gently scrape the secretions from the frog’s skin, and then release them into the jungle unharmed after their healing toxins are harvested.
It is not a drug or psychoactive and is legal to use around the world, except in parts of Australia where there is a ban on the administration, use or import.
Now, the rest of the world is becoming enlightened to the powerful kambo cleanse treatment, and you can benefit from Kambo’s powers outside of the deep Amazon jungle. You must find the right practitioner to assist you with your kambo cleanse.
What does Kambo do?
Do you feel that you have negative energies or emotional toxins that are holding you back from the life you want to have? Do you feel stressed and bogged down by your life? These negative energies can sabotage your desire for a peaceful, balanced life, causing physical and emotional distress. They can even thwart your dreams and your desires, taking away your courage and keeping you from pursuing the life you want. With this powerful cleanse, you can let go of what is holding you back, reignite your courage, pursue your dreams, reclaim your true self, and embrace joy.
The secretion can purify your body and mind, balancing each level of your being. It can systematically remove your distortions and impurities, giving you a deeper understanding of yourself and the life around you. It clarifies your mind and body and enlightens your spirit. It cleanses your body, emotions, and spirits to put you into a balanced, joyful, natural state.
What is a Kambo cleanse like?
It is important to always take kambo in a safe, supportive setting with an experienced practitioner. This will increase your chances of having the most positive experience possible. In a kambo ceremony, the secretion is applied to a person’s skin, usually on the arm, through tiny holes that are burned into the skin.
Different people may react differently to a kambo cleanse. It can cause you to sweat, shake, cry, vomit, get muscle cramps, or go into a state of bliss. It can be temporarily painful and make you feel ill; the kambo process takes around twenty minutes, and after a short rest, you will feel relaxed and realize the transformative power of the kambo cleanse and feel uplifted, purified, and happy. Even the people who experience the most negative side effects tend to come out of the cleanse, asking, “Can I do this again?”
After your cleanse, you may experience a powerful reduction in negative energies, a decrease in pain, and a feeling of joy and happiness. People often say they can’t say exactly what has shifted, but they feel a change. I cannot say that Kambo can heal or mention any health conditions, so please research online to find some of the magic stories (My story is under the “About Me” page. Whatever you are struggling with, mental, physical, or spiritual blockages, Kambo can be a powerful ally in shifting these blockages., Creating balance and realignment.s
What is the science?
Nobel prize nominee Vittorio Erspamer, a chemist and pharmacologist from the University of Rome, wrote extensively about the science behind kambo.
He identified and studied more than 60 chemical compounds, including the well-known serotonin. He once wrote that kambo contains “a fantastic chemical cocktail with potential medical applications, unequalled by any other amphibian.” His studies showed that some peptides could bind with receptor sites in the human brain, triggering beneficial reactions.
Kambo contains at least nine bioactive peptides that perform specific functions and affect human blood circulation, the adrenal cortex, the pituitary gland, the pancreas, and the gastrointestinal system:
Bradykinins (phyllokinin)
Tachykinins (phyllomedusin)
Cerulean
Sauvagine
Tryptophyllins
Dermorphins
Deltorphins
Bombesins
Andenoregulin
Some of these peptides are similar to our hormones, and others assist in vital cellular processes within the body. Scientists are working to isolate these peptides and study them further.
Unlike many other pharmaceuticals, kambo can cross the blood-brain barrier. This property allows it to treat conditions that are otherwise very difficult to treat.
However, there are currently no peer-reviewed studies to reference. While there is a lot of anecdotal evidence, there is no scientific evidence that the peptides in kambo will treat your medical conditions. Therefore, we will not make any medical claims until we have the science to back them up.
People have been using kambo as a treatment for hundreds of years. Some people have taken it in the Amazon rainforest more than 100 times in their lifetime. This shows that kambo, when used correctly, is a safe therapy. However, when used outside of the tribal setting with people who do not know how to use it correctly, problems may occur. You should always ensure that the practitioner administering your kambo cleanse is highly trained and experienced.
Please note that Kambo is not for you if you meet/have any of the following conditions:
Stroke.Pregnancy.Epilepsy.Heart bypass surgery.Enlarged heart.Implanted cardioverter-defibrillators.Pericardial effusion.Congestive heart disease.Excess fluid in the heart sack.Heart valve replacement.Organ transplant.Taking Diuretics.
Taking medicine for blood clots. Serious mental health problem (excluding PTSD, depression and anxiety) Bipolar disorder.Within a month of chemotherapy or radiotherapy. Taking. immunosuppressants for an organ transplantAddison’s disease.Recovering from a major surgical procedure.
A person that is water fasting for more than 12 hours.A person received an enema within 3 days prior. A person has consumed 5meoDMT (Bufo) in the past month. A person has consumed other strong plant medicine (e.g. San Pedro, Ayahuasca, Mushrooms) within 24 hours of wanting to receive Kambo. Some prescription drugs (I will check this with you before treatment)A person has not reached their 18th birthday. A person has reached their 70th birthday. The person is being coaxed into doing Kambo by another person (including a family member) The person lacks the mental capacity to decide to take Kambo. The person is desperate for a solution to a life-threatening problem. The person has consumed large amounts of water before arriving for the ceremony. A person has eaten within 8 hours of receiving Kambo. The person has not consumed 1-1.5L of water immediately before receiving Kambo.
This is not an exhaustive list, so please research or contact us.
In South Africa, I worked with a shaman/sangoma that worked mainly with water to heal. For years I worked with her and got to understand how powerful this element was. Water is the lifeblood of our mother earth the holiest being we will ever get to touch in this incarnation, used correctly water can bring balance and health.
She trained me to work with water and how to do spiritual baths, water root and river ceremonies. It was though her blessing and initiation that I now use water as a healing modality. Water was one of the first element that came into existence, and that makes it an ancient substance filled with wisdom.
People search the world for sacred water sites where they can immerse and experience oneness with God. Healing water rituals have existed in all cultures since recorded time and are thought to have existed in pre-historic cultures for millions of years. Most ancient cultures maintain spiritual creation stories crediting water as the origin of life.
Mythological stories of water deities have been passed down through oral traditions, and many continue to live on in modern religions and ceremonial traditions. Every culture on earth has a spiritual reverence for water and uses water symbolically in ceremony, christenings, baptisms, and initiations.
Many shrines have been constructed to praise the element of water; and often, these particular sites attract hundreds of thousands of people who make regular pilgrimages to participate in water healing rituals.
When water emerges from underground it is right there where it experiences its first exposure to light. This is the water that is thought to be most sacred, having emerged with all the resonance of the heart of the Earth still within its cells. These sacred wellsprings may be found in very remote places.
It is no surprise that people will travel through rugged terrain and suffer hardship in order to touch those pure waters. When the water has flowed over rocks, minerals, soil and roots, the energies present in each molecule are bursting with electromagnetic energy and have not been distorted by human contact or toxic resonance.
For thousands of years, cultures have performed water ceremonies.
Water Ceremonies in Egypt
Egyptian Priest and Anubis (Lord of the Dead) pouring water and water over King preparing him for his journey through the afterlife. The symbol of the Ankh represents water in the following pictures. The hieroglyphs depict Egyptian priest was bathing an Egyptian King with water and herbs depicted as ankh’s and one holding a sceptre in one hand and an ankh which represent eternal life.
Nile Water Ceremony Bath of Infants
Many believe that the Nubian infant bathing rituals date back to ancient Egypt. Generally, the ritual baths took place seven days after the birth of the child. A procession consisting of family and community elders walk to the river singing chants to the child’s spirit and asking the deities of the River Nile to protect and bless the child’s incarnation.
Food prepared by older women is offered to the Nile as a sacrifice while the men send a miniature boat with a white candle lite as a guild for the child’s earthly longevity. Many West African ethnic groups still perform the seven-day ceremony. For instance, among the Akans and Ga of Ghana, the birth ritual is done to confirm that the child was here to stay and would not return to the realm of the spirits.
Many of these rituals were brought from Africa to the Americas and continues to this day.
Piankhi Orders Soldiers to do Sacred Bath in the Nile
Piankhi /Piye of the 25th Dynasty of Egypt/ KMT has written one of the oldest military ritual baths in ancient history. Piankhi ruled over much of the modern-day Sudan and Egypt. He was a Nubian and recorded his military victory on a Stela. Piankhi considered his military conquest of Upper Egypt as a holy war to restore the shrines and temples. When his army entered the sacred city of Thebes, he ordered his men to do a ritual bath of the Nile stating
“When ye arrive at Thebes, before Karnak, ye shall enter into the water; ye shall bathe in the river, ye shall dress in [fine white linen], unstring the bow, loosen the arrow..”
The text above describes the Emperor’s religious preoccupation with paying homage to the unseen frequencies and powers that control the Nile. It is a glaring example of ritual purification, spiritual revitalization and cultural renewal.
Ritual Baths in the Bible
Ritual baths in the Bible were quite common. The oldest documented account of a spiritual ritual bath occurs in the Old Testament. John the Baptist were well known for doing his baptisms in rivers. There are many accounts of healing in and with water in Christianity.
“Where a spring rises or a water flows, there ought we to build altars and offer sacrifices.” Lucius Annaeus Seneca4 B.C. – 65 B.C
